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KMID : 0043320140370030399
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Archives of Pharmacal Research
2014 Volume.37 No. 3 p.399 ~ p.403
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Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans
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Thuong Phuong Thien
Hung Tran Manh
Khoi Nguyen-Minh
Nhung Hoang Thi My
Chinh Nguyen Thi
Quy Nguyen Thi
Jang Tae-Su
Na Min-Kyun
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Abstract
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Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.
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KEYWORD
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Myristica fragrans, Vietnamese nutmeg, Meso-dihydroguaiaretic acid, Cytotoxicity, Antitumor activity
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